iCS-digital TM Aneuploidy

The in Culture Supernatant – digital PCR Aneuploidy (iCS-digital TM Aneuploidy) test detects whole chromosome gains & losses in all chromosomes (22 autosome pairs and X and Y chromosomes) and in any human cell type.

iCS-digital TM Aneuploidy test steps Stem Genomics
Cell types

Any human cells

Stages

Any

Sample

Cell culture supernatant (> 70% confluence)

Shipment

Room temperature

Coverage

Aneuploidy of any of the 24 chromosomes: whole chromosome gains & losses

Mosaicism

10%

Time

2-3 days after sample reception

Rationale

Adult stem cells (mesenchymal, tissue-specific stem cells, etc.) are used in basic research and regenerative medicine. Their genomic stability during passaging is critical to avoid result misinterpretation, and unexpected complications in clinical therapies. Therefore, their genomic integrity should be regularly monitored.

By using 24 well-designed probes that target all 24 human chromosomes, the iCS-digital TM Aneuploidy test allows detecting whole chromosome gains and losses (trisomy, tetrasomy, monosomy, etc.).

This test is particularly useful to detect aneuploidy in adult stem cells, their differentiated derivatives and potentially any cell type. However, for embryonic and induced pluripotent stem cells, the iCS-digital TM Pluri test is more specific.

The iCS-digital TM Aneuploidy test is a non-invasive tool to detect whole chromosome gains & losses in the 24 human chromosomes for the routine monitoring of cell genomic stability. This new test can change how quality control is implemented for cell use in basic research and regenerative medicine.

iCS-digital TM Aneuploidy