iCS-digital TM Aneuploidy

The iCS-digital TM Aneuploidy test detects whole chromosome gains & losses
in all chromosomes (22 autosome pairs and X and Y chromosomes) and in any human cell type.

Cell types

Any human cells

Stages

Any

Samples

- gDNA
- Cell culture supernatant
(> 70% confluence)
- Cell pellet

Shipment

- Room temperature
- Room temperature
.
.
- Dry ice

Coverage

Aneuploidy of any of the 24 chromosomes: whole chromosome gains & losses

Mosaicism

>20%
(depending on sample quality)

Time

2-3 days
after sample reception

Rationale

Stem cells or adult cells are used in basic research and regenerative medicine. Their genomic stability during passaging is critical to avoid result misinterpretation, and unexpected complications in clinical therapies. Therefore, their genomic integrity should be regularly monitored.

By using 24 well-designed probes that target all 24 human chromosomes, the in Culture Supernatant-digital PCR (iCS-digital TM) Aneuploidy test allows detecting whole chromosome gains and losses (trisomy, tetrasomy, monosomy, etc.).

This test is particularly useful to detect aneuploidy in adult stem cells, their differentiated derivatives and potentially any cell type. However, for embryonic and induced pluripotent stem cells, the iCS-digital TM PSC test is more specific.

Example of a male cell line with trisomy 20

Aneuploidy test example

The iCS-digital TM Aneuploidy test is a non-invasive tool to detect whole chromosome gains & losses in the 24 human chromosomes for the routine monitoring of cell genomic stability. This new test can change how quality control is implemented for cell use in basic research and regenerative medicine.

iCS-digital TM Aneuploidy